How Vayarin® Works

Vayarin® is specially formulated for the distinctive nutrient needs resulting from ADHD. Vayarin® is an orally administered prescription medical food for the clinical dietary management of certain lipid imbalance associated with ADHD.


The unique composition in Vayarin® is Lipirinen™ 167 mg. Lipirinen™ is a proprietary composition containing phosphatidylserine-omega 3, EPA enriched.


While the exact mechanism by which Vayarin® exerts its effects is not fully understood, PS present in the mammalian nervous system, characterized by its high levels of omega-3 fatty acids, was found to affect cell signaling, metabolism and the activation of specific proteins in the brain, as well as other processes involved in learning ability and behavioral issues [1-6].


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References:

1. Mozzi, R., S. Buratta, and G. Goracci, Metabolism and functions of phosphatidylserine in mammalian brain. Neurochem Res, 2003. 28(2): p. 195-214. | 2. Wheeler, R.P.W., R. , ATPase activity of the sodium pump needs of phosphatidylserine. Nature, 1970. 225(5231): p. 449-450. | 3. Bittova, L., R.V. Stahelin, and W. Cho, Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity. J Biol Chem, 2001. 276(6): p. 4218-26. | 4. Vance, J.E., Phosphatidylserine and Phosphatidylethanolamine in Mammalian Cells: Two Metabolically-related Aminophospholipids. ASBMB, 2008: p. 1-48. | 5. Pepeu, G., I.M. Pepeu, and L. Amaducci, A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol Res, 1996. 33(2): p. 73-80. | 6. Mazzari, S. and A. Battistella, Phosphatidylserine effects on dopamine release from striatum synaptosomes. In: Multidisciplinary Approach to Brain Development. ElsevierNorth Holland Amsterdam, 1980. p. 569-570.